Mental and Physical Development of Preschool Children Born After Assisted Reproduction

This empirical study compared the mental (intellectual, personal, emotional, social) and physical development of four-year-old children conceived by assisted reproduction technology (ART) with that of naturally conceived children. The sample consisted of 90 ART children and 130 spontaneously conceived children (control). The research revealed no significant differences in behavior, emotional development, gender roles, intellectual development (visual-motor coordination, logical thinking, vocabulary, conceptual knowledge, speech development, counting and reading skills), physical development, emotional and behavioral eating habits, and dental health. The ART children demonstrated significantly higher symptoms of social developmental disorders and lower levels of categorizing skills, with a low effect size. The article introduces significant relationships across various components of mental development, as well as between mental and physical development of ART children vs. control. The majority of preschool children conceived by ART had normative development, but the study revealed a risk group and problem areas of development, which require monitoring and early correction.

1. Bokhan T. G., Silaeva A. V., Terekhina O. V., Shabalovskaya M. V., Leshchinskaia S. B., Gaifulina Ja. F. Influence of maternal health on mental development and health of children born through in vitro fertilization, in longitudinal study. Psychiatry, Psychotherapy and Clinical Psychology, 2022, 13(4): 407–420. (In Russ.) https://doi.org/10.34883/PI.2022.13.4.010

2. Golovey L. A., Savenysheva S. S., Engelgardt E. E. Family structure and upbringing as factors of intellectual development of preschool children. Social Psychology and Society, 2016, 7(3): 18–32. (In Russ.) https://doi.org/10.17759/sps.2016070302

3. Keshishian E. S., Tsaregorodtsev A. D., Ziborova M. I. The health status of children born after in vitro fertilization. Rossiyskiy Vestnik Perinatologii i Pediatrii, 2014, 59(5): 15–25. (In Russ.) https://www.elibrary.ru/swmgzb

4. Silaeva A. V. Mother's health as a factor in the mental development and health of children conceived by assisted reproductive technologies. Cand. Psych. Sci. Diss. Tomsk, 2021, 205. (In Russ.) https://www.elibrary.ru/wqipsn

5. Solovyeva E. V. Children conceived by IVF: specifics of mental development. Psikhologicheskaia nauka i obrazovanie www.psyedu.ru, 2014, 6(1): 261–272. (In Russ.)] https://doi.org/10.17759/psyedu.2014060129

6. Al-Hathlol K., Al-Obaid O. M., Al-Gholaiqa T. S., Al-Hathlol B., Abdulaal A. E., Al-Hajress R. I., Al-Joufi F. A., Al-Hassan N. F., Al-Otaibi A. G. School performance and long-term outcomes of very preterm children conceived via in vitro fertilization. JBRA Assisted Reproduction, 2020, 24(1): 61–65. https://doi.org/10.5935/1518-0557.20190063

7. Barbuscia A., Myrskylä M., Goisis A. The psychosocial health of children born after medically assisted reproduction: Evidence from the UK Millennium Cohort Study. SSM – Population Health, 2019, 7. https://doi.org/10.1016/j.ssmph.2019.100355

8. Berntsen S., Söderström-Anttila V., Wennerholm U. B., Laivuori H., Loft A., Oldereid N. B., Romundstad L. B., Bergh C., Pinborg A. The health of children conceived by ART: 'the chicken or the egg?'. Human Reproduction Update, 2019, 25(2): 137–158. https://doi.org/10.1093/humupd/dmz001

9. Carson C., Kurinczuk J. J., Sacker A., Kelly Y., Klemetti R., Redshaw M., Quigley M. A. Cognitive development following ART: effect of choice of comparison group, confounding and mediating factors. Human Reproduction, 2010, 25(1): 244–252. https://doi.org/10.1093/humrep/dep344

10. Côté S. M., Larose M.-P., Geoffroy M. C., Laurin J., Vitaro F., Tremblay R. E., Ouellet-Morin I. Testing the impact of a social skill training versus waiting list control group for the reduction of disruptive behaviors and stress among preschool children in child care: the study protocol for a cluster randomized trial. BMC psychology, 2017, 5(1). https://doi.org/10.1186/s40359-017-0197-9

11. Djuwantono T., Aviani J. K., Permadi W., Achmad T. H., Halim D. Risk of neurodevelopmental disorders in children born from different ART treatments: a systematic review and meta-analysis. Journal of Neurodevelopmental Disorders, 2020, 12. https://doi.org/10.1186/s11689-020-09347-w

12. Fauser B. C., Devroey P., Diedrich K., Balaban B., Bonduelle M., Delemarre-van de Waal H. A., Estella C., Ezcurra D., Geraedts J. P. M., Howles C. M., Lerner-Geva L., Serna J., Wells D. Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature. Reproductive BioMedicine Online, 2014, 28(2): 162–182. https://doi.org/10.1016/j.rbmo.2013.10.013

13. Golombok S., Rust G. The Pre-School Activities Inventory: A standardized assessment of gender role in children. Psychological Assessment, 1993, 5(2): 131–136.

14. Goodman R. The Strengths and Difficulties Questionnaire: a research note. Journal of Child Psychology and Psychiatry, 1997, 38(5): 581–586. https://doi.org/10.1111/j.1469-7610.1997.tb01545.x

15. Hart R., Norman R. J. The longer-term health outcomes for children born as a result of IVF treatment: Part I – General health outcomes. Human Reproduction Update, 2013a, 19(3): 232–243. https://doi.org/10.1093/humupd/dms062

16. Hart R., Norman R. J. The longer-term health outcomes for children born as a result of IVF treatment: Part II – Mental health and development outcomes. Human Reproduction Update, 2013b, 19(3): 244–250. https://doi.org/10.1093/humupd/dmt002

17. Heijligers M., Verheijden L. M. M., Jonkman L. M., van der Sangen M., Meijer-Hoogeveen M., Arens Y., van der Hoeven M. A., de Die-Smulders C. E. M. The cognitive and socio-emotional development of 5-year-old children born after PGD. Human Reproduction, 2018, 33(11): 2150–2157. https://doi.org/10.1093/humrep/dey302

18. Hvidtjørn D., Grove J., Schendel D., Schieve L. A., Sværke C., Ernst E., Thorsen P. Risk of autism spectrum disorders in children born after assisted conception: a population-based follow-up study. Journal of Epidemiology and Community Health, 2011, 65(6): 497–502. https://doi.org/10.1136/jech.2009.093823

19. Meijerink A. M., Ramos L., Janssen A. J. W. M., Maas-van Schaaijk N. M., Meissner A., Repping S., Mochtar M. H., Braat D. D. M., Fleischer K. Behavioral, cognitive, and motor performance and physical development of five-year-old children who were born after intracytoplasmic sperm injection with the use of testicular sperm. Fertility and sterility, 2016, 106(7): 1673–1682. https://doi.org/10.1016/j.fertnstert.2016.09.011

20. Oliver B. R., Dale P., Saudino K., Petrill S., Pike A., Plomin R. The validity of a parent-based assessment of cognitive abilities in three-year olds. Early Child Development and Care, 2002, 172(4): 337–348. https://doi.org/10.1080/03004430212713

21. Petrill S. A., Pike A., Price T., Plomin R. Chaos in the home and socioeconomic status are associated with cognitive development in early childhood: Environmental mediators identified in a genetic design. Intelligence, 2004, 32(5): 445–460. https://doi.org/10.1016/j.intell.2004.06.010

22. Rumbold A. R., Moore V. M., Whitrow M. J., Oswald T. K., Moran L. J., Fernandez R. C., Barnhart K. T., Davies M. J. The impact of specific fertility treatments on cognitive development in childhood and adolescence: A systematic review. Human Reproduction, 2017, 32(7): 1489–1507. https://doi.org/10.1093/humrep/dex085

23. Xing L.-F., Qu F., Qian Y.-L., Zhang F.-H., Zhu Y.-M., Xu X.-F. The social adaptation of children born after ICSI compared with IVF conceived children: A study from China. Journal of Obstetrics and Gynaecology, 2011, 31(8): 751–753. https://doi.org/10.3109/01443615.2011.606937

24. Zachor D. A., Ben Itzchak E. Assisted reproductive technology and risk for autism spectrum disorder. Research in Developmental Disabilities, 2011, 32(6): 2950–2956. https://doi.org/10.1016/j.ridd.2011.05.007