MOLECULAR GENETIC ANALYSIS OF DOUBLE-STRAND DNA BREAK REPAIR GENES POLYMORPHISM IN INDIGENOUS AND MIGRANT POPULATIONS
Abstract
АТМ Asp1853Asn, Lig4 Ala3Val, and NBS Glu185Gln genes polymorphism in two ethnic groups of Kemerovo region (the Shors and the Russians) has been studied. The frequency of minor АТМ1853Asn allele in the Shors group corresponds to the data obtained for Mongoloids (in various world populations) and is significantly lower than the inci dence of this allele in the Russians in Kemerovo region. The frequencies of Lig4¸ NBS1 alleles and genotypes in the. Russians and the Shors do not differ, as stated in the previous research. These data indicates a big share of the Mongolo id component in the genome of the indigenous people of Siberia – the Shors.
About the Authors
V. I. Minina
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics Kemerovo State University; Head of Cytogenetics Laboratory at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics Kemerovo State University; Head of Cytogenetics Laboratory at the Institute for Human Ecology of the Siberian branch of the RAS
V. G. Druzhinin
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Vladimir G. Druzhinin – Vice-Rector for Science of Kemerovo State University, Doctor of Biology; leading re searcher at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Vladimir G. Druzhinin – Vice-Rector for Science of Kemerovo State University, Doctor of Biology; leading re searcher at the Institute for Human Ecology of the Siberian branch of the RAS
A. A. Timofeeva
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at the Institute for Human Ecology of the Siberian branch of the RAS
A. V. Ryzhkova
Kemerovo State University
Russian Federation
Anastasiya V. Ryzhkova – student at
Russian Federation
Anastasiya V. Ryzhkova – student at
A. V. Larionov
Kemerovo State University
Russian Federation
Alexey V. Larionov – Lecturer at the Department of Genetics
Russian Federation
Alexey V. Larionov – Lecturer at the Department of Genetics
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Review
For citations:
Minina V.I., Druzhinin V.G., Timofeeva A.A., Ryzhkova A.V., Larionov A.V. MOLECULAR GENETIC ANALYSIS OF DOUBLE-STRAND DNA BREAK REPAIR GENES POLYMORPHISM IN INDIGENOUS AND MIGRANT POPULATIONS. SibScript. 2013;(2-1):21-25. (In Russ.)
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