POLYMORPHISM OF TWO LIG4 GENETIC MARKERS IN THE INDIGENOUS AND MIGRANT POPULATION OF KEMEROVO REGION
Abstract
The population genetic characteristics of two LIG4 polymorphic markers were examined in the indigenous (the Shors) and migrant (the Russians) population of Kemerovo region. The frequencies of genetic variants of Ala3Val polymorphism did not differ significantly between the two groups. At the same time a significant difference of the genotypes and allele polymorphism of Thr9Ile distributions between the ethnic cohorts was revealed. Minor allele Ile frequency among the representatives of the migrant population was almost three times as high as that of theindigenous ethnic group.
About the Authors
A. N. Volkov
Kemerovo State Medical Academy
Russian Federation
Aleksey N. Volkov – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Central Research Laboratory
Russian Federation
Aleksey N. Volkov – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Central Research Laboratory
A. I. Martinyuk
Kemerovo State Medical Academy
Russian Federation
Aleksander I. Martinyuk – post-graduate student at the Department of Genetics
Russian Federation
Aleksander I. Martinyuk – post-graduate student at the Department of Genetics
A. V. Larionov
Kemerovo State Medical Academy
Russian Federation
Alexey V. Larionov – engineer at the Department of Genetics
Russian Federation
Alexey V. Larionov – engineer at the Department of Genetics
D. K. Shihkova
Kemerovo State Medical Academy
Russian Federation
Darya K. Shishkova – 5th-year student at the Biological Faculty
Russian Federation
Darya K. Shishkova – 5th-year student at the Biological Faculty
V. I. Minina
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Institute for Human Ecology of the Siberian branch of the RAS
A. A. Timopheeva
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at theInstitute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at theInstitute for Human Ecology of the Siberian branch of the RAS
V. G. Druzhinin
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Vladimir G. Druzhinin – Doctor of Biology, Professor, Head of the Department of Genetics, Kemerovo State University; leading researcher at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Vladimir G. Druzhinin – Doctor of Biology, Professor, Head of the Department of Genetics, Kemerovo State University; leading researcher at the Institute for Human Ecology of the Siberian branch of the RAS
References
1. Breast cancer risk associated with genotypic polymorphism of the nonhomologous end-joining genes: a multigenic study on cancer susceptibility / Y-P. Fu [et al.] // Cancer Research. – 2003. – V. 63.
2. Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms / P.-M. Girard [et al.] // Human Molecular Genetics. – 2004. – V. 13.
3. Jeggo, P. A. DNA breakage and repair / P. A. Jeggo // Adv. Genet. – 1998. – V. 38.
4. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array / D. M. Kweekel [et al.] // British Journal of Cancer. – 2009. – V. 101.
5. Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathway / V. Margulis [et al.] // Cancer Epidemiol. Biomarkers Prev. – 2008. – V. 17.
6. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study / G. Matullo [et al.] // Carcinogenesis. – 2006. – V. 27(5).
7. Etiologic heterogeneity among non-Hodgkin lymphoma subtypes / L. M. Morton [et al.] // Blood. – 2008. – V. 112 (13).
8. Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient / E. Riballo [et al.] // Curr. Biol. – 1999. – V. 19.
9. Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination / P. L Roddam [et al.] // J. Med. Genet. – 2002. – V. 39.
10. Lung сancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes / R.-C. Tseng [et al.] // Cancer. – 2009. – № 1.
11. Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle–control genes / X. Wu [et al.] // American Journal of Human Genetics. – 2006. – V. 78. – С. 464 – 479.
12. Genetic polymorphisms in double-strand break DNA repair genes associate with risk of oral premalignant lesions / H. Yang [et al.] // Eur. J. Cancer. – 2008. – V. 44(11). – С. 1603 – 1611.
Review
For citations:
Volkov A.N., Martinyuk A.I., Larionov A.V., Shihkova D.K., Minina V.I., Timopheeva A.A., Druzhinin V.G. POLYMORPHISM OF TWO LIG4 GENETIC MARKERS IN THE INDIGENOUS AND MIGRANT POPULATION OF KEMEROVO REGION. SibScript. 2013;(1):12-15. (In Russ.)
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