kemsuСибСкриптSibScript2949-21222949-2092Kemerovo State Universitykemsu-3Research ArticleБиологияBiologyПОЛИМОРФИЗМ ДВУХ ГЕНЕТИЧЕСКИХ МАРКЕРОВ LIG4 У ПРЕДСТАВИТЕЛЕЙ КОРЕННОГО И ПРИШЛОГО НАСЕЛЕНИЯ КЕМЕРОВСКОЙ ОБЛАСТИPOLYMORPHISM OF TWO LIG4 GENETIC MARKERS IN THE INDIGENOUS AND MIGRANT POPULATION OF KEMEROVO REGIONВолковА. Н.VolkovA. N.

Волков Алексей Николаевич – кандидат биологических наук, доцент кафедры генетики, старший научный сотрудник центральной научно-исследовательской лаборатории.(384-2)580166, 89059493285, volkov_alex@rambler.ru

Aleksey N. Volkov – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Central Research Laboratory

volkov_alex@rambler.ruМартынюкА. И.MartinyukA. I.

Мартынюк Александр Игоревич – аспирант кафедры генетики

Aleksander I. Martinyuk – post-graduate student at the Department of Genetics

volkov_alex@rambler.ruЛарионовА. В.LarionovA. V.

Ларионов Алексей Викторович – инженер кафедры генетики

Alexey V. Larionov – engineer at the Department of Genetics

volkov_alex@rambler.ruШишковаД. К.ShihkovaD. K.

Шишкова Дарья Кирилловна – студентка 5 курса биологического факультета

Darya K. Shishkova – 5th-year student at the Biological Faculty

volkov_alex@rambler.ruМининаВ. И.MininaV. I.

Минина Варвара Ивановна – кандидат биологических наук, доцент кафедры генетики КемГУ, старший научный сотрудник учреждения РАН Института экологии человека СО РАН

Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; senior researcher at the Institute for Human Ecology of the Siberian branch of the RAS

volkov_alex@rambler.ruТимофееваА. А.TimopheevaA. A.

Тимофеева Анна Александровна – аспирант кафедры генетики КемГУ, инженер-технолог учреждения РАН Института экологии человека СО РАН

Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at theInstitute for Human Ecology of the Siberian branch of the RAS

volkov_alex@rambler.ruДружининВ. Г.DruzhininV. G.

Дружинин Владимир Геннадьевич – доктор биологических наук, профессор, заведующий кафедрой генетики КемГУ, ведущий научный сотрудник учреждения РАН Института экологии человека СО РАН.8(384-2)58-01-66, druzhinin_vladim@mail.ru

Vladimir G. Druzhinin – Doctor of Biology, Professor, Head of the Department of Genetics, Kemerovo State University; leading researcher at the Institute for Human Ecology of the Siberian branch of the RAS

druzhinin_vladim@mail.ruКемеровский государственный университетРоссияKemerovo State Medical AcademyRussian FederationКемеровский государственный университет; Институт экологии человека Сибирского отделения РАН, КемеровоРоссияKemerovo State University; Institute for Human Ecology of the Siberian branch of the RASRussian Federation201321022016011215Copyright © Волков А.Н., Мартынюк А.И., Ларионов А.В., Шишкова Д.К., Минина В.И., Тимофеева А.А., Дружинин В.Г., 20132013Волков А.Н., Мартынюк А.И., Ларионов А.В., Шишкова Д.К., Минина В.И., Тимофеева А.А., Дружинин В.Г.Volkov A.N., Martinyuk A.I., Larionov A.V., Shihkova D.K., Minina V.I., Timopheeva A.A., Druzhinin V.G.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibscript.ru/jour/article/view/3

Изучены популяционно-генетические характеристики двух полиморфных маркеров LIG4 среди коренного (шорцы) и пришлого (русские) населения Кемеровской области. Частоты генетических вариантов полиморфизма Ala3Val достоверно не отличались в двух группах. В то же время выявлено достоверное отличие распределений генотипов и аллелей полиморфизма Thr9Ile между этническими когортами. Среди представителей пришлого населения частота минорного аллеля Ile почти втрое превышала показатель, характерный для коренного этноса.

The population genetic characteristics of two LIG4 polymorphic markers were examined in the indigenous (the Shors) and migrant (the Russians) population of Kemerovo region. The frequencies of genetic variants of Ala3Val polymorphism did not differ significantly between the two groups. At the same time a significant difference of the genotypes and allele polymorphism of Thr9Ile distributions between the ethnic cohorts was revealed. Minor allele Ile frequency among the representatives of the migrant population was almost three times as high as that of theindigenous ethnic group.

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The authors declare that there are no conflicts of interest present.