Preview

SibScript

Advanced search

INVESTIGATION of ASSOCIATION of POLYMORPHISMs in ANXA5 AND CALB2 genes with increased risk of dental caries in preschool children

Abstract

Was studied polymorphism of genetic markers rs7676539 of ANXA5 and rs8063760 of CALB2 among preschool children сaucasian origin in Kemerovo, differing in the level of caries intensity. Alleles and genotypes frequencies of the studied sites in the sample were comparable to those typical for сaucasians in general. Unable to establish statistically significant differences between the frequency of any genetic variants of rs7676539 and rs8063760 in a cohort of healthy children compared with ones having very high intensity of dental caries.

Keywords


575.174.015.3: 616.31

About the Authors

Aleksey Nikolayevich Volkov
KemSU
Russian Federation


Larisa Juryevna Loshakova
KSMA
Russian Federation


Asia Damirovna Enikeeva
KemSU
Russian Federation


References

1. Волков, А. Н. Значение полиморфизма генов человека, участвующих в амелогенезе и формировании микросреды ротовой полости, для развития кариеса / А. Н. Волков, Л. Ю. Лошакова // Медицинская генетика. - 2011. - Т. 10. - № 2(104).

2. Волков, А. Н. Полиморфизм генетических маркеров rs2664152 и rs2664153, расположенных в 5'-области, по соседству с геном KLK4, среди детей дошкольного возраста с различным уровнем кариеса / А. Н. Волков, Л. Ю. Лошакова, А. С. Сухих // Медицинская генетика. - 2011. - Т. 10. - № 9(111).

3. Корчагина, В. В. Лечение кариеса зубов у детей раннего возраста. - М.: МЕДпресс-Информ, 2008. - 168 с.

4. Стоматологический уровень здоровья: рекомендации по методике определения / под ред. П. А. Леус. - М., 1990. - 39 с.

5. Deeley, K. Possible association of amelogenin to high caries experience in a Guatemalan-Mayan population / K. Deeley, A. Letra, E. K. Rose et al. // Caries Res. - 2008. - V. 42.

6. Homann, V. Calcium transport in human salivary glands: a proposed model of calcium secretion into saliva / V. Homann, E. Kinne-Saffran, W. H. Arnold et al. // Histochem Cell Biol. - 2006. - V. 125.

7. Ouryouji, K. Analysis of mutations in the amelogenin and the enamelin genes in severe caries in Japanese pediatric patients / K. Ouryouji, Y. Imamura, Y. Fujigaki et al. // Pediatric Dental Journal. - 2008. - V. 18.

8. Patir, A. Enamel formation genes are associated with high caries experience in Turkish children / A. Patir, F. Seymen, M. Yildirim et al. // Caries Res. - 2008. - V. 42.

9. Rajpar, M. H. Mutation of the gene encoding the enamel-specific protein, enamelin, causes autosomal-dominant amelogenesis imperfecta / M. H. Rajpar, K. Harley, C. Laing et al. // Hum. Molec. Genet. - 2001. - V. 10.

10. Tetè, S. Microarray expression profiling of human dental pulp from single subject / S. Tetè, F. Mastrangelo, A. P. Scioletti et al. // Clin Invest Med. - 2008. - V. 31(2).

11. Gerke, V. Annexins: from structure to function / V. Gerke, S. E. Moss // Physiol Rev. - 2002. - V. 82.

12. Wescott, D. C. Osteogenic gene expression by human periodontal ligament cells under cyclic tension / D. C. Wescott, M. N. Pinkerton, B. J. Gaffey et al. // J Dent Res. - 2007. - V. 86(12).

13. Wright, J. T. Human and mouse enamel phenotypes resulting from mutation or altered expression of AMEL, ENAM, MMP20 and KLK4 / J. T. Wright, T. C. Hart, P. S. Hart // Cells Tissues Organs. - 2009. - V. 189.


Review

For citations:


Volkov A.N., Loshakova L.J., Enikeeva A.D. INVESTIGATION of ASSOCIATION of POLYMORPHISMs in ANXA5 AND CALB2 genes with increased risk of dental caries in preschool children. The Bulletin of Kemerovo State University. 2012;(1):11-14. (In Russ.)

Views: 160


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2949-2122 (Print)
ISSN 2949-2092 (Online)