LIPOSOMAL VEGF DEPOSITION AFTER INTRAMYOCARDIAL AND SYSTEMIC ADMINISTRATION IN EXPERIMENTAL MYOCARDIAL INFARCTION
Abstract
Liposomal VEGF of various diameter were examined for their organ distribution following intramyocardial and systemic administration in a model of myocardial infarction. Liposomes were found to stay in the myocardium after intramyocardial administration. Besides, smaller liposomes were more intensively absorbed by cells. No liposomal deposition in the brain was observed.
About the Authors
E. A. Velikanova
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
Elena A. Velikanova – junior researcher at Cell Technology Laboratory
Russian Federation
Elena A. Velikanova – junior researcher at Cell Technology Laboratory
A. S. Golovkin
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
Alexey S. Golovkin – Candidate of Medicine, Head of Experimental and Clinical Cardiology Department
Russian Federation
Alexey S. Golovkin – Candidate of Medicine, Head of Experimental and Clinical Cardiology Department
R. A. Mukhamadiarov
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
Rinat A. Mukhamadiarov – Candidate of Biology, leading researcher at Laboratory for Ultrastructural Tissue Studies
Russian Federation
Rinat A. Mukhamadiarov – Candidate of Biology, leading researcher at Laboratory for Ultrastructural Tissue Studies
Yu. G. Toropova
Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
Yana G. Toropova – researcher at Cell Technology Laboratory
Russian Federation
Yana G. Toropova – researcher at Cell Technology Laboratory
G. V. Lisachenko
Kemerovo State Medical Academy
Russian Federation
Gennady V. Lisachenko – Doctor of Medicine, Professor, Head of the Department of Pathological Phisiology
Russian Federation
Gennady V. Lisachenko – Doctor of Medicine, Professor, Head of the Department of Pathological Phisiology
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Review
For citations:
Velikanova E.A., Golovkin A.S., Mukhamadiarov R.A., Toropova Yu.G., Lisachenko G.V. LIPOSOMAL VEGF DEPOSITION AFTER INTRAMYOCARDIAL AND SYSTEMIC ADMINISTRATION IN EXPERIMENTAL MYOCARDIAL INFARCTION. SibScript. 2013;(1):8-12. (In Russ.)
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