OPTIMIZATION OF PHYSICAL, MECHANICAL AND DEGRADATION PROPERTIES FOR BIODEGRADABLE ANTI-ADHESIVE MEMBRANES
Abstract
Biodegradation rate and tensile strength are essential for membranes, applied to prevent post-surgical adhesion formation. The study is aimed at evaluating biodegradation rate, physical and mechanical properties of the membranes made from biodegradable polymer composites in vitro, namely polyhydroxybutyrate / oxovalerate (PGBV), polylactide (PLA), and polylactide-co-glycolide (PLGA). PLGA copolymers, having a polylactide: glycolide ratio in the proportion of 70:30 and 60:40, reported the highest biodegradation rate, moreover, the addition of PGBV to this polymer composite may increase the bioresorption rate of the latter by1.2 – 1.3 times. Thus, the physical and mechanical testing findings have shown that the addition of PLGA to PGBV results in improved properties of the studied samples – PLGA added to the polymer composite in the proportion 60:40 increased its strength by 27.5 %, and its elastic properties by 70 % compared to PGBV. The obtained results demonstrated that the adjustment of the bioresorbable polymer formulation for anti-adhesive membranes may regulate biodegradation rate, physical and mechanical properties.
About the Authors
M. V. Nasonova
Research Institute for Complex Issues of Cardiovascular Disease of the Siberian Branch the RAMS, Kemerovo
Russian Federation
Marina V. Nasonova – Research Associate at the Laboratory of New Biomaterials
Russian Federation
Marina V. Nasonova – Research Associate at the Laboratory of New Biomaterials
Yu. I. Hodyrevskaya
Research Institute for Complex Issues of Cardiovascular Disease of the Siberian Branch the RAMS, Kemerovo
Russian Federation
Yulia I. Khodyrevskaya – Junior Research Associate at the Laboratory of New Biomaterials
Russian Federation
Yulia I. Khodyrevskaya – Junior Research Associate at the Laboratory of New Biomaterials
A. I. Nemoykina
Томский государственный университет
Russian Federation
Anna L. Nemoykina – Candidate of Biology, Head of the Laboratory of Biopolymers and Biotechnology
Russian Federation
Anna L. Nemoykina – Candidate of Biology, Head of the Laboratory of Biopolymers and Biotechnology
M. Yu. Mikhaylenko
Mikhail Yu. Mikhaylenko – engineer at the Laboratory of Biopolymers and Biotechnology
Russian Federation
Mikhail Yu. Mikhaylenko – engineer at the Laboratory of Biopolymers and Biotechnology
Russian Federation
Mikhail Yu. Mikhaylenko – engineer at the Laboratory of Biopolymers and Biotechnology
Yu. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Disease of the Siberian Branch the RAMS, Kemerovo
Russian Federation
Yuliya A. Kudryavtseva – Doctor of Biology, Head of the Laboratory of New Biomaterials
Russian Federation
Yuliya A. Kudryavtseva – Doctor of Biology, Head of the Laboratory of New Biomaterials
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Review
For citations:
Nasonova M.V., Hodyrevskaya Yu.I., Nemoykina A.I., Mikhaylenko M.Yu., Kudryavtseva Yu.A. OPTIMIZATION OF PHYSICAL, MECHANICAL AND DEGRADATION PROPERTIES FOR BIODEGRADABLE ANTI-ADHESIVE MEMBRANES. SibScript. 2015;1(2-1):65-69. (In Russ.)
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