DNA DAMAGE IN MINERS (LITERATURE REVIEW)
Abstract
In the process of coal mining, workers (both in mines and open pits) are exposed to a whole range of factors. However, studies aimed at in-depth analysis of DNA damage in miners, are still few. In this review, we analyze the results of cytogenetic studies conducted in various coal mining companies in the world. Results of studies show a significant accumulation of chromosomal aberrations in miners’ blood cells, sister chromatid exchanges, micronuclei and DNA strand breaks, detected by DNA comets. This illustrates the need for similar studies in Kuzbass and the feasibility of developing and implementing protective measures and prevention programmes for miners, aimed at protecting their genomes.
About the Authors
Yu. E. Kulemin
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Yuriy E. Kulemin – post-graduate student at the Departament of Genetics, Kemerovo State University, engineer
Russian Federation
Yuriy E. Kulemin – post-graduate student at the Departament of Genetics, Kemerovo State University, engineer
V. I. Minina
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Departament of Genetics; Head of Cytogenetics Laboratory
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Departament of Genetics; Head of Cytogenetics Laboratory
R. A. Titov
Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Russian Federation
Ruslan A. Titov – post-graduate student, engineer
References
1. Баранов В. С., Кузнецова Т. В. Цитогенетика эмбрионального развития человека. СПБ: Н-Л., 2007. 640 с.
2. БочковН. П., Чеботарев А. Н., Катосова Л. Д., Платонова В. И. База данных для анализа количественных характеристик частоты хромосомных аберраций в культуре лимфоцитов периферической крови человека // Генетика. 2001. Т. 37. № 4. С. 549 – 557.
3. Бочков Н. П., Шрам Р. Я., Кулешов Н. П., Журков B. C. Система оценки химических веществ на мутагенность для человека: общие принципы, практические рекомендации и дальнейшие разработки // Генетика. 1975. Т. II. № 10. С. 156 – 169.
4. Бочков Н. П., Чеботарев А. Н. Наследственность человека и мутагены внешней среды. М.: Медицина, 1989. 170 с.
5. Захаров А. Ф., Бенюш В. А., Кулешов Н. П., Барановская Л. И. Хромосомы человека. М.: Медицина, 1982. 264 с.
6. Синицкий М. Ю.Использование микроядерного теста для оценки генотоксического воздействия радона на организм человека // Радиоэкология XXI века: материалы Междунар. науч.-практ. конф. Красноярск, 2012. С. 428 – 432.
7. Тронов В. А., Пелевина И. И. Метод ДНК-комет индивидуальных клеток. Принцип и применение метода // Цитология. 1996. Т. 38. № 4/5. С. 71 – 75.
8. Хорошилова Л. С., Табакаева Л. М., Харин Д. В. О профессиональной заболеваемости работников угольной отрасли промышленности Кузбасса // Безопасность труда в промышленности. 2008. № 10.
9. Buckton K. E., Evans H. J. Methods for the Analysis of Human Chromosome Aberrations. 66 Seiten, 25 Abb. und 9 Tab. World Health Organization. Geneva 1973. Preis: 3,60$, 1,50 £, 12, Sw. fr.
10. Celic M., Donbak L., Unal F., Yuzbasioglu D., Aksoy H., Yilmaz S. Cytogenetic damage in workers from a coal-fired power plant // Mutation Research 627 (2007). Р. 158 – 163.
11. Donbak L., Rencuzogullar E., Yavuz A., Topaktas M. The genotoxic risk of underground coal miners from Turkey // Genetic Toxicology and Environmental Mutagenesis, 2005. 588, 82 – 7.
12. Fenech M., Morley A. A. Solutions to the kinetic problem in the micronucleus assay // Cytobios, 1985. № 43. P. 233 – 246.
13. Fenech M. The in vitro micronucleus technique // Mutation Research, 2000. № 455. P. 81 – 95.
14. Finkelman R. B., Orem W., Castranova V., Tatu C. A., Beklin H. E., Zheng B., Lerch H. E., Maharaj S. V. Health impacts of coal and coal use: possible solutions A. L. Bates Int J Coal Geol, 2002. 50. Р. 425 – 430.
15. Hamza V. Z., Mohankumar M. N. Cytogenetic damage in human blood lymphocytes exposed in vitro to radon Mutat. Res. 2009. 661 (1-2): 1-9.
16. Hsu T. C. Genetic instability in the human population: a working hypothesis // Hereditas, 1998. № 4. P. 1 – 9.
17. León-Mejía G., Espitia-Pérez L., Hoyos-Giraldo L. S. Assessment of DNA Damage in Coal Open-Cast Mining Workers Using the Cytokinesis-Blocked Micronucleus Test and the Comet Assay // Science of the Total Environment, 2011. 409. Р. 686 – 691.
18. Liu J., Hutchison K., Perrone-Bizzozero N., Morgan M., Sui J. Identification of Genetic and Epigenetic Marks Involved in Population Structure. 2010.
19. Mészáros G., Bognár G., Köteles G. J. Long-Term Persistence of Chromosome Aberrations in Uranium Miners // Journal of Occupational Health, 2004. 46. Р. 310 – 315.
20. Mukherjee A. K., Bhattacharya S. K., Saiyed H. N. Assessment of respirable dust and its free silica contents in Different Indian coalmines // Ind Health, 2005. 43. Р. 277 – 84.
21. Müller W. U., Kryscio A., Streffer C. Micronuclei in lymphocytes of uranium miners of the former Wismut SDAG // Cytogenet Genome Res. 2004. 104(1-4): 295 – 8.
22. Olive P. L., Banáth J. P. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 2006; 1 (1): 23 – 9.
23. Ostling O., Johanson K. J. Microelectrophoretic study of radiation-induced DNA damage in individual mammalian cells. Biochem Biophys Res Commun, 1984. 123: 291 – 8.
24. Rohr P., Kvitko K., Silva F. R., Menezes A. P., Porto C., Sarmento M., Decker N., Reyes J. M., Allgayer Mda C., Furtado T. C., Salvador M., Branco C. J. da SilvaGenetic and oxidative damage of peripheral blood lymphocytes in workers with occupational exposure to coal // Mutat Res. 2013 Dec 12; 758(1-2): 23-8. doi: 10.1016/j.mrgentox. 2013.08.006. Epub 2013 Sep 1.
25. Sergio R., Maria S., Arana M., Ramirez O. Chromosomal aberrations in peripheral lymphocytes from male native miners working in the Peruvian Andes // Genetics and Molecular Biology. 2007. 30. 4. Р. 1135 – 1138.
26. Ulker O. C., Ustundag A., Duydu Y., Yucesoy B., Karakaya A. Cytogenetic monitoring of coal workers and patients with coal workers' pneumoconiosis in Turkey // Environ Mol Mutagen. 2008. Apr; 49(3): 232-7 doi: 10.1002/em.20377.
27. Zölzer F., Hon Z., Skalická Z. F., Havránková R., Navrátil L., Rosina J., Škopek J. Micronuclei in lymphocytes from currently active uranium miners // Radiat Environ Biophys. 2012 Aug; 51(3): 277-82. doi: 10.1007/s00411-0120422-0. Epub 2012 May 24.
Review
For citations:
Kulemin Yu.E., Minina V.I., Titov R.A. DNA DAMAGE IN MINERS (LITERATURE REVIEW). SibScript. 2014;(3-3):11-15. (In Russ.)
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