CONTRIBUTION OF DNA REPAIR ENZYMES GENES POLYMORPHISM TO CHROMOSOMAL MUTAGENESIS IN HUMAN LYMPHOCYTES (REVIEW)
Abstract
A review of scientific publications on the analysis of the correlation between chromosome aberrations and DNA repair enzymes genes polymorphism in healthy individuals and cancer patients is provided. The paper presents prospects of using SNP in the DNA repair enzymes genes as markers of increased sensitivity to clastogenes. The importance of such studies for the residents of the industrial region is proved.
About the Author
V. I. Minina
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; Head of Cytogenetics Laboratory at the Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics, Kemerovo State University; Head of Cytogenetics Laboratory at the Institute for Human Ecology of the Siberian branch of the RAS
References
1. Засухина, Г. Д. Генетический полиморфизм в защите клеток человека от мутагенов / Г. Д. Засухина, Н. С. Кузьмина // Молекулярный полиморфизм человека / под ред. С. Д. Варфоломеева. – М.: РУДН, 2007.
2. Хромосомные аберрации и полиморфизм генов эксцизионной репарации у работников СХК с онкологическими заболеваниями / Г. Н. Мансурова [и др.] // Сибирский онкологический журнал. – 2008. – Приложение № 1.
3. Исследование взаимосвязи между полиморфизмом генов репарации ДНК и частотой хромосомных аберраций в лимфоцитах крови больных раком легкого / В. И. Минина [и др.] // Бюллетень ВСНЦ СО РАМН. – 2012. – № 3 (85). – Ч. 2.
4. Сальникова, Л. Е. Полиморфизм генов репарации и цитогенетические эффекты облучения / Л. Е. Сальникова, А. Г. Чумаченко, И. Н. Веснина // Радиационная биология. Радиоэкология. – 2010. – Т. 50. – № 6.
5. Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK / A. A. Affatato [et al.] // Environ Mol Mutagen. – 2004. – Vol. 44(1). – С. 65 – 73.
6. Apurinic/apyrimidinic endonuclease (APE1) gene polymorphisms and lung cancer risk in relation to tobacco smoking / B. Agachan [et al.] // Anticancer Res. – 2009. – V. 29(6).
7. Benhamou, S. ERCC2/XPD polymorphisms and lung cancer / S. Benhamou, A. Sarasin // Am J Epidemiol. – 2005. – Vol. 161.
8. Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer / C. Harms [et al.] // Environ Mol Mutagen. – 2004. – Vol. 44(1).
9. Case LD: amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity / J. J. Hu [et al.] // Carcinogenesis. – 2001. – V. 22.
10. Micronuclei and chromosomal aberrations, important markers of ageing: possible association with XPC and XPD polymorphisms / A. Kazimírová [et al.] // Mutat Res. – 2009. – Vol. 661(1 – 2).
11. Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA / T. Kohno [et al.] // Oncogene. – 1998. – V. 16. – С. 3219 – 3225.
12. The ADPRT V762A genetic variant contributes to prostate cancer susceptibility and deficient enzyme function / K. Lockett [et al.] // Cancer Research. – 2004. – V. 64.
13. Nemec, A. Variant base excision repair proteins: Contributors to genomic instability / A. Nemec, S. Wallace, J. Sweasy // Seminars in Cancer Biology. – 2010. – Vol. 20.
14. XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking / B. F. Pachkowski [et al.] // Cancer Res. – 2006. – V. 66.
15. Polymorphisms of the DNA Repair Gene XRCC1 and Lung Cancer Risk / D. Ratnasinghe [et al.] // Cancer Epidemiology, Biomarkers & Prevention. – 2001. – V. 10.
16. Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies / C. F. Skjelbred [et al.] // Mutat Res. – 2006. – Vol. 602(1 – 2). Erratum in Mutat Res. – 2007. – Vol. 624(1-2).
17. Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: effects on levels of sister chromatid exchanges and chromosomal aberrations / J. Tuimala [et al.] // Mutat Res. – 2004. – Vol. 554(1-2).
18. Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA / P. Vodicka [et al.] // Carcinogenesis. – 2004. – Vol. 5.
19. Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature / J. M. Weiss [et al.] // Mol. Carcinog. – 2005. – V. 42(3).
Review
For citations:
Minina V.I. CONTRIBUTION OF DNA REPAIR ENZYMES GENES POLYMORPHISM TO CHROMOSOMAL MUTAGENESIS IN HUMAN LYMPHOCYTES (REVIEW). SibScript. 2013;(1):34-38. (In Russ.)
Views:
397
Email this article 