POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION
Abstract
XRCC1 Arg280His, XRCC2 Arg188His, XRCC3 Thr241Met genes polymorphism in lung cancer patients and healthy people of Kemerovo region has been studied. It is established that in the studied samples of distribution of frequencies of alleles and genotypes of the studied polymorphic markers had no deviation from Hardy-Weinberg equilibrium. The prevalence of XRCC3Met in the group of patients with lung cancer is statistically significantly higher than in healthy people. Also, there was a decrease in the frequency of Thr/Thr homozygotes of the XRCC3 gene in male patients with lung cancer. The obtained data are of significant interest for epidemiological studies of hereditary predisposition to the development of lung cancer.
About the Authors
A. V. Ryzhkova
Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Anastasiya V. Ryzhkova – post-graduate student, engineer
Russian Federation
Anastasiya V. Ryzhkova – post-graduate student, engineer
V. I. Minina
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Departament of Genetics, Kemerovo State University; Head of Cytogenetics Laboratory
Russian Federation
Varvara I. Minina – Candidate of Biology, Assistant Professor at the Departament of Genetics, Kemerovo State University; Head of Cytogenetics Laboratory
M. L. Bakanova
Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Marina L. Bakanova – Junior Research Associate
Russian Federation
Marina L. Bakanova – Junior Research Associate
R. A. Titov
Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Ruslan A. Titov – post-graduate student, engineer
Russian Federation
Ruslan A. Titov – post-graduate student, engineer
Yu. E. Kulemin
Kemerovo State University; Institute for Human Ecology of the Siberian branch of the RAS
Russian Federation
Yuriy E. Kulemin – post-graduate student at the Departament of Genetics, engineer
Russian Federation
Yuriy E. Kulemin – post-graduate student at the Departament of Genetics, engineer
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Review
For citations:
Ryzhkova A.V., Minina V.I., Bakanova M.L., Titov R.A., Kulemin Yu.E. POLIMORPHISM OF XRCC1, XRCC2, XRCC3 GENES IN LUNG CANCER PATIENTS AND HEALTHY PEOPLE OF KEMEROVO REGION. SibScript. 2014;(3-3):26-29. (In Russ.)
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