kemsuСибСкриптSibScript2949-21222949-2092Kemerovo State Universitykemsu-63Research ArticleБиологияBiologyМОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЙ АНАЛИЗ ПОЛИМОРФИЗМА ГЕНОВ РЕПАРАЦИИ ДВУНИТЕВЫХ РАЗРЫВОВ ДНК У КОРЕННОГО И ПРИШЛОГО НАСЕЛЕНИЯ КЕМЕРОВСКОЙ ОБЛАСТИMOLECULAR GENETIC ANALYSIS OF DOUBLE-STRAND DNA BREAK REPAIR GENES POLYMORPHISM IN INDIGENOUS AND MIGRANT POPULATIONSМининаВ. И.MininaV. I.

Минина Варвара Ивановна – кандидат биологических наук, доцент кафедры генетики КемГУ, завудующая лабораторией цитогенетики ИЭЧ СО РАН

Varvara I. Minina – Candidate of Biology, Assistant Professor at the Department of Genetics Kemerovo State University; Head of Cytogenetics Laboratory at the Institute for Human Ecology of the Siberian branch of the RAS

vminina@mail.ruДружининВ. Г.DruzhininV. G.

Дружинин Владимир Геннадьевич – проректор по науке КемГУ, доктор биологических наук, главный научный сотрудник ИЭЧ СО РАН

Vladimir G. Druzhinin – Vice-Rector for Science of Kemerovo State University, Doctor of Biology; leading re searcher at the Institute for Human Ecology of the Siberian branch of the RAS

druzhinin_vladim@mail.ruТимофееваА. А.TimofeevaA. A.

Тимофеева Анна Александровна – аспирант КемГУ, инженер-технолог ИЭЧ СО РАН

Anna A. Timofeeva – post-graduate student at the Department of Genetics, Kemerovo State University; engineer at the Institute for Human Ecology of the Siberian branch of the RAS

coldunica@mail.ruРыжковаА. В.RyzhkovaA. V.

Рыжкова Анастасия Владимировна – студент 5 курса КемГУ

Anastasiya V. Ryzhkova – student at

vminina@mail.ruЛарионовА. В.LarionovA. V.

Ларионов Алексей Викторович – ассистент кафедры генетики КемГУ

Alexey V. Larionov – Lecturer at the Department of Genetics

vminina@mail.ruКемеровский государственный университет; Институт экологии человека Сибирского отделения РАН, КемеровоРоссияKemerovo State University; Institute for Human Ecology of the Siberian branch of the RASRussian FederationКемеровский государственный университетРоссияKemerovo State UniversityRussian Federation20132202201602-12125Copyright © Минина В.И., Дружинин В.Г., Тимофеева А.А., Рыжкова А.В., Ларионов А.В., 20132013Минина В.И., Дружинин В.Г., Тимофеева А.А., Рыжкова А.В., Ларионов А.В.Minina V.I., Druzhinin V.G., Timofeeva A.A., Ryzhkova A.V., Larionov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibscript.ru/jour/article/view/63

Проведено исследование полиморфизма генов АТМ Asp1853Asn, Lig4 Ala3Val, NBS1 Glu185Gln в двух эт нических группах Кемеровской области (шорцы, русские). Распространенность минорного аллеля АТМ Asn в группе шорцев соответствует данным, полученным для монголоидов, и статистически значимо ниже, чем у русских Кемеровской области. Частоты аллелей и генотипов гена Lig4¸ NBS1 у русских и шорцев не различа ются и соответствуют данным литературы. Эти данные свидетельствуют о высоком удельном весе монголоид ного компонента в геноме коренного населения Сибири – шорцев.

АТМ Asp1853Asn, Lig4 Ala3Val, and NBS Glu185Gln genes polymorphism in two ethnic groups of Kemerovo region (the Shors and the Russians) has been studied. The frequency of minor АТМ1853Asn allele in the Shors group corresponds to the data obtained for Mongoloids (in various world populations) and is significantly lower than the inci dence of this allele in the Russians in Kemerovo region. The frequencies of Lig4¸ NBS1 alleles and genotypes in the. Russians and the Shors do not differ, as stated in the previous research. These data indicates a big share of the Mongolo id component in the genome of the indigenous people of Siberia – the Shors.

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The authors declare that there are no conflicts of interest present.