kemsuСибСкриптSibScript2949-21222949-2092Kemerovo State Universitykemsu-1269Research ArticleИстория и археологияHistory and archeologyОПТИМИЗАЦИЯ СРОКОВ ДЕГРАДАЦИИ И ФИЗИКО-МЕХАНИЧЕСКИХ СВОЙСТВ ПРОТИВОСПАЕЧНЫХ МЕМБРАН НА ОСНОВЕ БИОДЕГРАДИРУЕМЫХ ПОЛИМЕРОВOPTIMIZATION OF PHYSICAL, MECHANICAL AND DEGRADATION PROPERTIES FOR BIODEGRADABLE ANTI-ADHESIVE MEMBRANESНасоноваМ. В.NasonovaM. V.mv-nas@mail.ruХодыревскаяЮ. И.HodyrevskayaYu. I.aiger2350@yandex.ruНемойкинаА. Л.NemoykinaA. I.

Anna L. Nemoykina – Candidate of Biology, Head of the Laboratory of Biopolymers and Biotechnology

nemoykina@rambler.ruМихайленкоМ. Ю.MikhaylenkoM. Yu.mendeleev_tip@mail.ruКудрявцеваЮ. А.KudryavtsevaYu. A.kudrua@cardio.kem.ruНаучно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний, КемеровоРоссияResearch Institute for Complex Issues of Cardiovascular Disease of the Siberian Branch the RAMS, KemerovoRussian FederationТомский государственный университетРоссияТомский государственный педагогический университетРоссияMikhail Yu. Mikhaylenko – engineer at the Laboratory of Biopolymers and BiotechnologyRussian Federation20152303201612-16569Copyright © Насонова М.В., Ходыревская Ю.И., Немойкина А.Л., Михайленко М.Ю., Кудрявцева Ю.А., 20152015Насонова М.В., Ходыревская Ю.И., Немойкина А.Л., Михайленко М.Ю., Кудрявцева Ю.А.Nasonova M.V., Hodyrevskaya Y.I., Nemoykina A.I., Mikhaylenko M.Y., Kudryavtseva Y.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.sibscript.ru/jour/article/view/1269

Для мембран, предназначенных для профилактики образования спаек после полостных операций, важны такие показатели, как срок биодеградации и упруго-прочностные характеристики. Цель настоящего исследования – оценить сроки биодеградации in vitro и физико-механические свойства мембран, изготовленных на основе композиций биодеградируемых полимеров: полигидроксибутирата/оксивалерата (PGBV), полилактида (PLA) и полилактида-ко-гликолида (PLGA). Показано, что полученные сополимеры PLGA в соотношении полилактид/гликолид – 70/30 и 60/40 обладают наиболее быстрыми сроками биодеградации и в композиции с PGBV позволяют увеличить скорость биорезорбции последнего в 1,2 – 1,3 раза. При этом результаты физико-механических испытаний образцов свидетельствуют, что добавление PLGA к PGBV позволяет улучшить свойства исследуемых образцов – при добавлении в полимерную композицию PLGA 60/40 прочность образцов увеличивается на 27,5 %, а упруго-эластические свойства увеличиваются на 70 % по сравнению с PGBV. Полученные результаты свидетельствуют, что регулируя состав биорезорбируемых полимерных мембран, можно влиять на скорость биодеградации и физико-механические свойства.

Biodegradation rate and tensile strength are essential for membranes, applied to prevent post-surgical adhesion formation. The study is aimed at evaluating biodegradation rate, physical and mechanical properties of the membranes made from biodegradable polymer composites in vitro, namely polyhydroxybutyrate / oxovalerate (PGBV), polylactide (PLA), and polylactide-co-glycolide (PLGA). PLGA copolymers, having a polylactide: glycolide ratio in the proportion of 70:30 and 60:40, reported the highest biodegradation rate, moreover, the addition of PGBV to this polymer composite may increase the bioresorption rate of the latter by1.2 – 1.3 times. Thus, the physical and mechanical testing findings have shown that the addition of PLGA to PGBV results in improved properties of the studied samples – PLGA added to the polymer composite in the proportion 60:40 increased its strength by 27.5 %, and its elastic properties by 70 % compared to PGBV. The obtained results demonstrated that the adjustment of the bioresorbable polymer formulation for anti-adhesive membranes may regulate biodegradation rate, physical and mechanical properties.

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The authors declare that there are no conflicts of interest present.